Evidence from Randomised Controlled Trials (if this is how we base our decisions) on supplement use in mental health. I would add a word of caution with regard to SAMe and EFAs. According to Dr. William Walsh, PhD, who has studied the individual chemistry of thousands of people diagnosed with mental illness, those individuals who are over-methylators would deteriorate on SAMe and those with severe pyrrole disease would deteriorate on omega 3 EFAs. Finding out about your individual chemistry is necessary in tailoring management, rather than being a statistic in the “did not respond” category.